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Neurophysiology of epilepsy and neurodevelopmental disorders

Peer-reviewed publications

Recent publications:

Chancey JH, Ahmed AA, Guillén FI, Ghatpande V, Howard MA. Complex Synaptic and Intrinsic Interactions Disrupt Input/Output Functions in the Hippocampus of Scn1b Knock-Out Mice. J Neurosci. 2023 Dec 6;43(49):8562-8577. doi: 10.1523/JNEUROSCI.0786-23.2023. PMID: 37845033; PMCID: PMC10711733.

Chancey JH, Howard MA. Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in the Scn1a Haploinsufficiency Mouse Model of Dravet Syndrome. eNeuro. 2022 May 17;9(3):ENEURO.0080-22.2022. doi: 10.1523/ENEURO.0080-22.2022. PMID: 35523580; PMCID: PMC9116933.

Past publications:

Casalia ML, Howard MA, Baraban SC (2017). Persistent seizure control in epileptic mice transplanted with GABA progenitors. Annals of Neurology, 82, 530-42.


Pla R, Stanco A, Howard MA, Vogt D, Rubin A, Mortimer N, Cobos I, Potter GP, Lindtner S, Scott C. Baraban, Rowitch DH, Rubenstein JLR (2017). Dlx1/2 promote interneuron GABA synthesis, synaptogenesis, and dendritogenesis. Cerebral Cortex, 28, 1-19.


Howard MA, Baraban SC (2016). Synaptic integration of transplanted interneuron progenitor cells into native cortical networks. Journal of Neurophysiology, 116, 472-8.


Silbereis JC, Nobuta H, Tsai H-H, Heine VM, McKinsey GL, Meijer DH, Petryniak MA, Potter GP, Howard MA, Alberta JA, Baraban SC, Stiles CD, Rubenstein JLR, Rowitch DH (2014). Olig1 function is required to repress Dlx1/2 and interneuron production in mammalian brain. Neuron, 81, 574-87.


Howard MA, Rubenstein JLR, Baraban SC (2014). Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo. Proceedings of the National Academy of Science, USA, 111, 492-7.


Russell JF, Steckley JL, Coppola G, Hahn AF, Howard MA, Kornberg Z, Huang A, Mirsattari SM, Merriman B, Klein E, Choi M, Lee HY, Kirk A, Nelson-Williams C, Gibson G, Baraban SC, Lifton RP, Geschwind DH, Fu YH, Ptáček LJ (2012). Familial cortical myoclonus with a mutation in NOL3. Annals of Neurology, 72, 175-83.


Jones DL, Howard MA, Stanco A, Rubenstein JL, Baraban SC (2011). Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons. Journal of Neurophysiology, 105, 1984-91.


Howard MA, Elias GM, Elias LA, Swat W, Nicoll RA (2010).  The role of SAP97 in synaptic glutamate receptor dynamics. Proceedings of the National Academy of Science, USA, 107, 3805-10.


Howard MA, Rubel EW (2010). Dynamic spike thresholds during synaptic integration preserve and enhance temporal response properties in the avian cochlear nucleus. Journal of Neuroscience, 30, 12063-74.


Howard MA, Burger RM, Rubel EW (2007).  A developmental switch to GABAergic inhibition dependent on increases in Kv1-type K+ currents.  Journal of Neuroscience, 27, 2112-23.


Martin GL, Vazquez AE, Jimenez AM, Stagner BB, Howard MA, Lonsbury-Martin BL (2007).  Comparison of distortion product otoacoustic emissions in 28 inbred strains of mice.  Hearing Research, 234, 59-72.


Howard MA, Stagner BB, Lonsbury-Martin BL, Martin GK (2003).  Suppression tuning in noise exposed rabbits.  Journal of the Acoustical Society of America, 114, 279-93.


Howard MA, Rodenas-Ruana AI, Henkemeyer M, Martin GK, Lonsbury-Martin BL, Liebl DJ (2003).  Eph receptor deficiencies lead to altered cochlear function.  Hearing Research, 178, 118-30.


Cunningham CL, Ferree NK, Howard MA (2003).  Initial cue bias and place conditioning. Psychopharmacology, 170, 409-22.


Kinoshita K, Chatzipanteli K, Alonso OF, Howard MA, Dietrich WD (2002).  The effect of brain temperature on hemoglobin extravasation after traumatic brain injury.  Journal of Neurosurgery, 97, 945-953.


Howard MA, Stagner BB, Lonsbury-Martin BL, Martin GK (2002).  Effects of reversible noise exposure on the suppression tuning of rabbit distortion-product otoacoustic emissions.  Journal of the Acoustical Society of America, 111, 285-96.


Cunningham CL, Howard MA, Gill SJ, Rubinstein M, Low MJ, Grandy DK (2000). Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice.  Pharmacology, Biochemistry and Behavior, 67, 693-9.


Howard MA, Baraban SC (2017). Catastrophic epilepsies of childhood.  Annual Review of Neuroscience, 40, 149-166.

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